๐งฌ Basics of Genetic Analysis
๐
Friday, July 25, 2025 | ๐ 8:00 am โ 12:00 pm
๐ Westin Harbour Castle โ Pier 2, Toronto, Canada
๐ฅ In-person attendance only
๐ฏ Summary and Setup
This immersive ISTAART workshop provides an introduction to the fundamentals of genetic analysis within brain imaging genetics research. It combines theoretical concepts with hands-on practical sessions to give attendees a solid foundation.
๐ป Connecting to Your Virtual Machine
Participants will access a cloud-hosted Linux-based VM with pre-installed tools. You should have received two emails from no-reply@accounts.eu-west-2.amazonappstream.com
.
- One for initial login/password setup
- One for app launch (AppStream Desktop)
๐ซ If you havenโt received the email, contact a facilitator.
๐๏ธ Agenda
Time | Session | Speaker(s) |
---|---|---|
8:00 am | Welcome / Intro | Tavia Evans |
8:10 am | How to design your genetics experiment | Natalia Vilor-Tejedor |
8:20 am | How to get data, QC, and imputation | Natalia Vilor-Tejedor |
9:00 am | SNP analysis | Yuetiva Robles |
9:40 am | Break | ย |
9:50 am | Genome Wide Association Studies (GWAS) | Yuetiva Robles |
10:40 am | Polygenic Risk Score (PRS) calculation with PRSice | Emma Luckett |
11:35 am | PostGWAS analysis: Understanding biological pathways | Krishna Rani Kalari, Karunya Kandimalla |
11:55 am | End / Review | Tavia Evans, Natalia Vilor-Tejedor, Junhao Wen |
๐ Learning Objectives
- Perform basic genetic analyses (SNPs, GWAS, PRS).
- Understand and compare different genetic techniques.
- Interpret outputs in the context of imaging genetics.
๐ Requirements
- Bring your own laptop (tablets wonโt work)
- Review pre-recorded webinars (linked below)
- Use the provided VM environment for all exercises
๐ Webinars & Slides
Webinar Topic | Slides |
---|---|
Design your genetics experiment | Slides Intro |
QC and Imputation | Slides QC Imputation, Pipeline QC, Pipeline Imputation |
Single SNP association analysis | Slides SNP association |
Genome Wide Association Studies | Slides GWAS |
Polygenic Risk Scores | Slides PRS |
PostGWAS analysis | Slides postGWAS |
๐ฅ Organizing Committee
- Tavia E Evans, PhD
- Natalia Vilor-Tejedor, PhD
- Junhao Wen, PhD
- David M Cash, PhD
- Tobey J. Betthauser, PhD
Speakers
- Natalia Vilor-Tejedor, PhD
- Yuetiva Robles, PhD
- Emma Luckett, PhD
- Karunya Kandimalla, PhD
- Krishna Rani Kalari, PhD
Teaching Aids
- Luigi Lorenzini, PhD
- Blanca Rodriguez-Fernandez, MSc
- Patricia Genius, MSc
- Armand Gonzalez-Escalante, MSc
This workshop is supported by: Alzheimerโs Association, ISTAART Neuroimaging PIA - Working group Brain Imaging Genetics
Special thanks to ADNI datasets, and infrastructure support from UCL team.
Interested in learning more? Check out our recent book chapter: Vilor-Tejedor, N. et al. (2025). Genomics and Transcriptomics of Alzheimer Disease. In: Tarawneh, R. (eds) Biomarkers of Neurodegenerative Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-80849-4_13.
ยฉ 2025 AAIC Workshop Basics of Genetics โข Maintained by @GeneticNeuroStats
Hosted on GitHub Pages